FDA溶出度方法库(AI中文)2730条
药品名称
剂型
USP溶出方法
转速（转/min）
溶出介质
容积
荐采样时间
更新时间
Midostaurin
Capsule
II (Paddle)
50
Tier 1:Deionized water with 0.5% Polysorbate 20; Tier 2: Deionized water with 0.5% Polysorbate 20 containing pepsin
900
5, 10, 15, 20, 30 and 45
11/02/2017
Midodrine HCl
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Miconazole Nitrate
Suppository (Vaginal)
I (Basket)
100
0.45% SLS in water
900
15, 30, 45 and 60
10/08/2009
Miconazole
Tablet (Buccal)
I (Basket)
60
0.5% SDS (Sodium dodecylsulfate) in water-pH adjusted to 6.5 ± 0.5
1000
1, 2, 4, 6, 8, 10 and 12 hours
10/28/2010
Mexiletine HCl
Capsule
Refer to FDA's Dissolution Guidance, 2018
04/22/2021
Metyrosine
Capsule
Refer to USP
02/15/2018
Metronidazole
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Metronidazole
Capsule
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Metoprolol Tartrate
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Metoprolol Succinate
Tablet (Extended Release)
Refer to USP
07/25/2007
Metolazone
Tablet
Refer to USP
04/02/2020
Metoclopramide HCl
Tablet
Refer to USP
07/15/2009
Metoclopramide HCl
Tablet (Orally Disintegrating)
I (Basket)
50
Water
900
5, 10, 15, 20, 30 and 45
04/08/2010
Methyltestosterone
Tablet
II (Paddle)
50
Water
900
10, 20, 30, 45, 60 and 75
07/31/2013
Methyltestosterone
Capsule
Refer to USP
07/31/2013
Methylprednisolone Acetate
Injectable Suspension
IV (Flow-Through Cell-Open system)
0.55 % SDS
15, 30, 45, 60, 90 and 120
10/08/2009
Methylprednisolone
Tablet
Refer to USP
01/29/2010
Methylphenidate HCl (25 mg, 35 mg, 45 mg, 55 mg, 70 mg and 85 mg)
Capsule (Extended Release)
II (Paddle) with sinker
75
Acid Stage:(0-6 hours) Simulated Gastric Fluid [SGF, pH 1.2] without enzyme; Buffer Stage (after six hours in acid stage): Phosphate Buffer, pH 7.4
Acid Stage: 0.5, 1, 2, 4, 6 hours; Buffer Stage: 1, 2, 4, 6, 8 and 10 hours
04/02/2020
Methylphenidate HCl
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Methylphenidate HCl
Powder for Suspension (Extended Release)
II (Paddle)
75
0.4 M Phosphate Buffer, pH 4.5
900
0.25, 0.5, 1, 2, 3, 4, 6 and 8 hours
06/02/2016