FDA溶出度方法库(AI中文)2730条
药品名称
剂型
USP溶出方法
转速（转/min）
溶出介质
容积
荐采样时间
更新时间
Methylphenidate HCl
Tablet (Extended Release, Chewable)
II (Paddle)
75
0.4M KH2PO4 solution (degas)
900
0.25, 0.5, 1, 2, 3, 4, 6, 8 hours
03/17/2016
Methylphenidate HCl
Tablet (Chewable)
I (Basket)
100
Water
900
15, 30, 45 and 60
03/25/2010
Methylphenidate HCl
Capsule (Extended Release)
I (Basket)
100
Acid Stage:(First 2 hours) 0.01 N HCl; Buffer Stage (2-10 hours): Phosphate Buffer, pH 6.0
0.5, 1, 2, 4, 6, and 10 hours
10/20/2016
Methylphenidate (BX)
Capsule (Extended Release)
I (Basket)
75
0-2 hrs:0.01 N HCl. 2-10 hrs: Phosphate Buffer, pH 6.8.
0.5, 1, 3, 6, 8 and 10 hours
07/25/2007
Methylphenidate
Tablet (Extended Release, Orally Disintegrating )
II (Paddle)
75
Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8
Acid Stage: 15, 30, 60, 120 minutes; Buffer Stage: 1, 2, 3, 4, 6 and 8 hours
11/16/2017
Methylphenidate
Transdermal Patch
VI (Cylinder)
50
0.01 N HCl at 32ºC
900
0.5, 1.5, 3, 4 hours and until at least 80% released
04/15/2008
Methylphenidate
Capsule (Extended Release)
II (Paddle)
50
Water
500
1, 2, 4, 6, 8, 12 hours and until at least 80% released
04/15/2008
Methylphenidate
Tablet (Extended Release)
Refer to USP
02/14/2014
Methylnaltrexone Bromide
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Methylergonovine Maleate
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Methscopolamine Bromide
Tablet
Refer to USP
02/15/2018
Methoxsalen
Capsule
Refer to USP
03/25/2010
Methotrexate Sodium
Tablet
Refer to USP
04/02/2009
Methocarbamol
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Methimazole
Tablet
Refer to USP
01/14/2008
Methenamine Hippurate
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Methazolamide
Tablet
II (Paddle)
100
pH 4.5 Acetate Buffer
900
10, 15, 20, 30 and 45
05/28/2015
Methadone HCl
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Metformin/Repaglinide
Tablet
II (Paddle)
50
Citric acid/phosphate buffer, pH 5.0
900
5, 10, 15, 20 and 30
10/30/2009
Metformin HCl/Sitagliptin Phosphate
Tablet
II (Paddle)
75
0.025 M NaCl
900
10, 15, 20 and 30
10/06/2008