FDA溶出度方法库2730条
药品名称
剂型
USP溶出方法
转速（转/min）
溶出介质
容积
荐采样时间
更新时间
Cevimeline HCL
Capsule
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Chlorambucil
Tablet
II (Paddle)
75
0.1 N HCl
900
10, 20, 30, and 45
08/17/2006
Chlordiazepoxide HCl/ Clidinium Bromide
Capsule
Refer to USP (provide individual unit data).
03/02/2017
Chloroquine Phosphate
Tablet
Refer to FDA's Dissolution Guidance, 2018
04/16/2020
Chlorothiazide
Suspension
Develop a dissolution method
03/07/2019
Chlorpheniramine Maleate
Tablet (Extended Release)
III (Reciprocating Cylinder)
Row 1: Test Fluid 1 (0.1N HCl) for 1st hour. Row 2: Test fluid 2 (Phosphate Buffer, pH 7.5) for 5th hour
1 hour for test fluid 1, and 4 hours for test fluid 2
07/25/2007
Chlorpheniramine Maleate/Codeine Phosphate
Tablet (Extended Release)
II (Paddle)
50
Simulated gastric fluid (SGF) without enzyme (pH 1.2)
900
0.5, 1, 2, 4, 6, 8 and 12 hours
10/20/2016
Chlorpheniramine Maleate/Ibuprofen/Phenylephrine HCl
Tablet
II (Paddle)
50
50 mM Potassium Phosphate Buffer, pH 6.5 (degassed)
900
5, 10, 15, 20 and 30
06/25/2015
Chlorpheniramine Maleate/Ibuprofen/Pseudoephedrine HCl
Tablet
II (Paddle)
50
0.05 M Phosphate Buffer, pH 6.5
900
10, 20, 30 and 45
02/20/2004
Chlorpheniramine Polistirex/ Codeine polistirex
Suspension (Extended Release)
II (Paddle)
50
Acid Stage: 0.1 N HCl; Buffer Stage: pH 6.8 Phosphate Buffer [500 mL 0.1 N HCl for 1 hour, followed by addition of 400 mL of 0.2M NaH2P04 to pH 6.8]
Acid Stage: 1 hour; Buffer Stage: 1, 2, 4, 6, 8 and 12 hours
03/17/2016
Chlorpheniramine Polistirex/Hydrocodone Polistirex
Capsule (Extended Release)
II (Paddle)
50
Simulated Intestinal Fluid without enzyme
500
1, 4, 12, and 24 hours
11/25/2008
Chlorpheniramine Polistirex/Hydrocodone Polistirex
Extended Release Oral Suspension
II (Paddle)
50
Simulated Gastric Fluid (SGF) at 37ºC ± 0.5ºC
495
1, 2, 3, 6, 8, 12, 16 and 24 hours
06/30/2011
Chlorpromazine HCl
Tablet
Refer to USP
01/05/2012
Chlorthalidone
Tablet
Refer to USP
04/15/2008
Chlorzoxazone
Tablet
Refer to USP
01/14/2008
Cholic Acid
Capsule
II (Paddle) with sinker
100
Phosphate Buffer, pH 6.8
5, 10, 15, 20 and 30
03/17/2016
Choline Fenofibrate
Capsule (Delayed Release)
II (Paddle)
50
Acid Stage: 0.05M Sodium Phosphate, pH 3.5 ± 0.05; Buffer Stage: 0.05 M Sodium Phosphate, pH 6.8 ± 0.05
Acid stage: 120; Buffer stage: 15, 30, 60, 90, 120, 240 and 360
07/01/2010
Ciclopirox
Topical Suspension
Develop a method to characterize in vitro release
03/25/2010
Cilostazol
Tablet
II (Paddle)
75
0.3% SLS in water
900
15, 30, 45, 60 and 90
08/17/2006
Cinacalcet HCl
Tablet
II (Paddle)
75
0.05 N HCl
900
10, 20, 30 and 45
01/26/2006