FDA溶出度方法库2730条
药品名称
剂型
USP溶出方法
转速（转/min）
溶出介质
容积
荐采样时间
更新时间
Canagliflozin
Tablet
II (Paddle)
75
0.75 % sodium lauryl sulfate (SLS) in water
600
5, 10, 15, 20 and 30
06/02/2016
Canagliflozin (Can)/ Metformin HCl (Met)
Tablet (Extended Release)
Met: I (Basket, 40 mesh): Can: I (Basket, 10 mesh [with option of tablet holder])
Met: Simulated Gastric Fluid [SGF] without enzyme, pH 1.2; Can: 0.1% (w/v) polysorbate 20 in 0.05 M sodium phosphate buffer pH 6.8 ( 50 mg); 0.2% (w/v) polysorbate 20 in 0.05 M sodium phosphate buffer pH 6.8 (150 mg)
Met: 1, 2, 4, 6, 8 10 and 12 hours: Can: 10, 15, 20, 30, 45 and 60 minutes;
12/22/2016
Canagliflozin/Metformin HCl
Tablet
II (Paddle)
Canagliflozin (50 mg): 0.025 % Polysorbate 20; Canagliflozin (150 mg):0.075 % Polysorbate 20; Metformin: Phosphate buffer, pH 6.8
Canagliflozin: 10, 15, 20, 30 and 45; Metformin: 5, 10, 15, 20 and 30
05/28/2015
Candesartan Cilexetil (16 mg, 8 mg and 4 mg)
Tablet
II (Paddle)
50
0.35% Polysorbate 20 in 0.05 M Phosphate Buffer, pH 6.5
900
10, 20, 30, 45 and 60
06/20/2007
Candesartan Cilexetil (32 mg)
Tablet
II (Paddle)
50
0.70% Polysorbate 20 in 0.05 M Phosphate Buffer, pH 6.5
900
10, 20, 30, 45 and 60
06/20/2007
Candesartan Cilexetil/Hydrochlorothiazide (16/12.5 mg)
Tablet
II (Paddle)
50
0.35% Polysorbate 20 in phosphate buffer pH 6.5
900
10, 20, 30, 45 and 60
01/29/2010
Candesartan Cilexetil/Hydrochlorothiazide (32/12.5 mg and 32/25 mg)
Tablet
II (Paddle)
50
0.70% Polysorbate 20 in phosphate buffer pH 6.5
900
15, 20, 30, 45 and 60
01/29/2010
Capecitabine
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Capecitabine
Tablet
Refer to USP
11/02/2017
Captopril
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Carbamazepine
Suspension
II (Paddle)
50
Water (deaerated)
900
10, 20, 30, 45 and 60
01/20/2004
Carbamazepine
Capsule (Extended Release)
II (Paddle)
75
First 4 hours: Dilute Acid, pH 1.1. After 4 hours: Phosphate Buffer, pH 7.5 with 0.1% sodium lauryl sulfate (SLS).
1, 2, 4, 6, 8, 10 and 12 hours
09/01/2011
Carbamazepine
Tablet (Extended Release)
Refer to USP
01/14/2008
Carbamazepine
Tablet
Refer to USP
12/24/2015
Carbamazepine
Tablet (Chewable)
II (Paddle
75
1% SLS in Water
900
15, 30, 45, 60 and 90
12/23/2010
Carbidopa
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Carbidopa/Entacapone/Levodopa
Tablet
I (Basket)
For both Carbidopa and Levodopa: 0.1 N HCl, For Entacapone: Phosphate buffer pH 5.5
10, 20, 30, 45 and 60
01/03/2007
Carbidopa/Levodopa
Tablet
Refer to FDA's Dissolution Guidance, 2018
04/22/2021
Carbidopa/Levodopa
Tablet (Extended Release)
II (Paddle)
50
0.1 N HCl
900
0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours
08/15/2013
Carbidopa/Levodopa
Tablet (Orally Disintegrating)
II (Paddle)
50
0.1 N HCl
750
5, 10, 15, 30, and 45
07/25/2007