FDA溶出度方法库2730条
药品名称
剂型
USP溶出方法
转速（转/min）
溶出介质
容积
荐采样时间
更新时间
Betrixaban
Capsule
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Bexarotene
Capsule
II (Paddle)
50
Tier 1 Medium: 0.5% HDTMA in 0.05 M phosphate buffer, pH 7.5 Tier 2 Medium: 0.5% HDTMA in 0.05 M phosphate buffer, pH 7.5 with 0.05 g/L pancreatin enzyme
900
15, 30, 45 and 60
08/17/2006
Bicalutamide
Tablet
II (Paddle)
50
1% SLS in water
1000
10, 20, 30, 45 and 60
12/15/2005
Bisacodyl/Polyethylene glycol 3350/ Potassium Chloride/Sodium Bicarbonate/ Sodium Chloride
Tablet (Delayed Release), For Solution,
II (Paddle)
100
Acid stage: 0.1 N HCl: Buffer stage: 0.05 M Phosphate buffer, pH 6.8, with 0.15% sodium lauryl sulfate (SLS) [only for Bisacodyl Tablets]
Acid stage: 60; Buffer stage: 10, 20, 30, 45 and 60
03/02/2017
Bismuth Subcitrate Potassium/Metronidazole/Tetracycline HCl
Capsule
II (Paddle)
75
Tetracycline and Metronidazole: 0.1 N HCl; Bismuth Subcitrate Potassium: Water
900
5, 15, 20, 30 and 45
10/06/2008
Bisoprolol Fumarate
Tablet
Refer to FDA's Dissolution Guidance, 2018
07/02/2020
Bisoprolol Fumarate/Hydrochlorothiazide
Tablet
II (Paddle)
75
0.1 N HCl
900
5, 10, 20, 30 and 45
01/20/2004
Boceprevir
Capsule
II (Paddle) with sinker
50
50 mM phosphate buffer, pH 6.8 with 0.1% sodium dodecyl sulfate
900
10, 20, 30, 45, 60 and 75
01/31/2013
Bosentan
Tablet (For Suspension)
II (Paddle)
75
0.1 N HCl with 0.5% sodium dodecyl sulfate (SDS), pH 1.1
900
5, 10, 15, 20 and 30
11/16/2017
Bosentan
Tablet
II (Paddle)
50
1% SLS in water
900
15, 30, 45 and 60
09/02/2010
Bosutinib Monohydrate
Tablet
II (Paddle)
50
0.1 N HCl
900
10, 15, 20, 30 and 45
06/25/2015
Brexpiprazole
Tablet
II (Paddle)
50
0.05 M Acetate buffer, pH 4.3
900
10, 15, 20, 30 and 45
10/20/2016
Brigatinib
Tablet
II (Paddle)
70
50 mM Potassium Phosphate Buffer, pH 7.2
900
5, 10, 15, 20, 30 and 45
11/02/2017
Brimonidine Tartrate/Brinzolamide
Ophthalmic Suspension
Develop a method to characterize in vitro release
01/15/2015
Brinzolamide
Ophthalmic Suspension
Develop a method to characterize in vitro release
09/01/2011
Brivaracetam
Tablet
II (Paddle
50
Phosphate Buffer, pH 6.4
5, 10, 15, 20 and 30
07/28/2016
Bromocriptine Mesylate
Tablet
Refer to USP
07/25/2007
Budesonide
Tablet (Extended Release)
II (Paddle)
100
Acid Stage: 0.1 M HCl containing 0.5% Macrogol Cetostearyl Ether; Buffer Stage: pH 7.2 phosphate buffer containing 0.5% Macrogol Cetostearyl Ether.
Acid Stage: 2 hours; Buffer Stage: 1, 2, 4, 6, 8 and 10 hours
04/02/2015
Budesonide
Capsule
II (Paddle) with sinker
75
Acid stage: 0.1 N HCl; Buffer stage: Phosphate Buffer, pH 7.5
Acid stage: 2 hours; Buffer stage: 0.25, 0.5, 1, 2, 4, 6 and 8 hours
02/25/2015
Bumetanide
Tablet
Refer to USP
07/14/2008